Our gene expressions are what make us individuals and what make us share familial traits. Blood diseases, like thalassemia for example, are determined by a gene, HBA1, on the long arm of our 16th chromosome, spanning 872 nucleotides. Being able to screen parents to see whether they are carriers of the recessive gene will allow us to make decisions that our parents, grandparents, great grandparents, … never were able to make.
Genetic diseases, like the ones mentioned in the GATTACA movie we saw (worksheet), are also located in specific places on our karyotype. For example, I have hemochromatosis, just like my father and his brother. Mutations in the HAMP, HFE, HFE2, SLC40A1, and TFR2 genes cause hereditary hemochromatosis.
Genetic Research Worksheets:
Two students cannot research the same genetic disease. Tell the professor which one you want to research to reserve it for yourself. Breast cancer and diabetes are not researchable.
Genetic Disease: Hemochromatosis
Symptoms/Conditions: Iron accumulates in the tissues, it can cause heart disease, fatigue, joint pain, abdominal pain, and loss of sex drive. Later signs and symptoms can include arthritis, liver disease, diabetes, heart abnormalities, and skin discoloration.
Gene #1: hepcidin antimicrobial peptide
Gene Symbol: HAMP
Chromosome #: 19
Cytogenetic Location: 19q13.12
Start Base Pair: 35,282,346
End Base Pair: 35,285,143
Normal Function: It produces a protein called hepcidin. It maintains iron balance in the body.
Gene #2: hemochromatosis
Gene Symbol: HFE
Chromosome #: 6
Cytogenetic Location: 6p22.2
Start Base Pair: 26,087,281
End Base Pair: 26,096,216
Normal Function: The HFE protein interacts with other proteins on the cell surface to detect the amount of iron in the body.
News Article #1: FDA Sued for Failure to Regulate Deadly Bacteria in Raw Oysters
News Article #2: Ancient Irish DNA indicates mass migration from Middle East
News Article #3: Rare Condition Means Another Dry St. Patrick’s Day
Here’s how the info fits on the research page–> sample research